Use of the LMA-ProSeal in an experimental pig model -- a potential animal model for laryngeal mask airway research: results of a pilot study

• Published in: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Vol. 41; no. 4; p. 223
• Main Authors: Goldmann, K, Kalinowski, M, Dieterich, J, Wulf, H
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2006
• Subjects: Anesthesia; Animals; Blood Gas Analysis; Laryngeal Masks; Pilot Projects; Positive-Pressure Respiration; Prone Position - physiology; Respiratory Function Tests; Supine Position - physiology; Swine
• ISSN: 0939-2661
• DOI: 10.1055/s-2006-924992

In light of the increased use of the LMA-ProSeal (P-LMA) it seems desirable to consider the P-LMA for prolonged surgical cases or post-operative ventilation. Long-term use could carry the risk of serious complications. An experimental pig model could be used to gain basic knowledge about long-term use before conducting clinical trails. In this randomized controlled study we tested the hypothesis if prolonged positive pressure ventilation (PPV) with the P-LMA in the pig is possible. The P-LMA was used for airway maintenance under general anaesthesia and PPV in 15 German country pigs. Randomised into 3 groups, the animals were ventilated for 90, 150 and 390 minutes, respectively. Arterial blood gas measurements were used to determine adequacy of ventilation. Airway leak pressure (P (leak)) and maximum tidal volume (TV) were measured in the supine, lateral and prone positions. A bronchoscopic examination was performed to detect signs of aspiration. Adequate ventilation was demonstrated both after 120 min (4.7 +/- 0.4 kPa) and 360 min (4.7 +/- 0.5 kPa). The corresponding PaO(2) at FiO(2) = 1.0 was 59 +/- 5 kPa and 64 +/- 10 kPa, respectively. The mean P (leak) was 34 +/- 7 cm H(2)O. Change of position did not result in any significant change in P(leak) or maximum TV kg (-1). There was no bronchoscopic evidence of aspiration in any pig. It was possible to ensure sufficient PPV with the P-LMA in the pig over different periods of time and in different body positions without any complications of airway management. The P-LMA can be used for PPV in the pig for durations of up to 390 minutes. We conclude that investigations into the long-term use of the LMA can be carried out in a pig model.