Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation

• Published in: Pharmaceutics Vol. 16; no. 7; p. 854
• Main Authors: Denduyver, Phaedra, Birk, Gudrun, Ambruosi, Alessandra, Vervaet, Chris, Vanhoorne, Valérie
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.06.2024
• Subjects: binders; Contact angle; continuous manufacturing; formulation optimization; Manufacturing; Molecular weight; Particle size; Polyvinyl alcohol; twin-screw granulation; Viscosity; Water; wet granulation; United Kingdom > UK; France; United States > US; Germany; formulation optimization; continuous manufacturing; twin-screw granulation; binders; polyvinyl alcohol; wet granulation

Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2-40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was identified as an effective binder during TSWG...