Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus
In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippoca...
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Published in | Neural regeneration research Vol. 7; no. 3; pp. 197 - 201 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
India
Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China%Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China
25.01.2012
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Online Access | Get full text |
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Summary: | In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway. |
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Bibliography: | sericin; type 2 diabetes mellitus; hippocampus; apoptosis; Akt signal transduction pathway; neural regeneration Zhihong Chen1, Yaqiang He1, Chengjun Song1, Zhijun Dong2, Zhejun Su2, Jingfeng Xue1 1Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China 2Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway. 11-5422/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Zhihong Chen, Doctor, Professor, Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China Author contributions: Zhihong Chen was in charge of funds, conceived and designed the study, analyzed data and wrote the manuscript. Yaqiang He analyzed the data. Chengjun Song fed the animals and provided experimental data. Zhijun Dong and Zhejun Su conducted the statistical analysis. Jingfeng Xue conceived and designed the study, revised the manuscript and guided the study. |
ISSN: | 1673-5374 1876-7958 |
DOI: | 10.3969/j.issn.1673-5374.2012.03.007 |