Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus

In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippoca...

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Published inNeural regeneration research Vol. 7; no. 3; pp. 197 - 201
Main Authors Chen, Zhihong, He, Yaqiang, Song, Chengjun, Dong, Zhijun, Su, Zhejun, Xue, Jingfeng
Format Journal Article
LanguageEnglish
Published India Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China%Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China 25.01.2012
Medknow Publications & Media Pvt Ltd
Subjects
2型糖尿病
Akt
Research and Report: Traditional Chinese Medicine and Neuroregeneration
丝胶蛋白
信号转导通路
大鼠模型
核因子kappa
海马CA1区
神经细胞凋亡
Akt signal transduction pathway
type 2 diabetes mellitus
apoptosis
sericin
neural regeneration
hippocampus
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Summary:In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.
Bibliography:sericin; type 2 diabetes mellitus; hippocampus; apoptosis; Akt signal transduction pathway; neural regeneration
Zhihong Chen1, Yaqiang He1, Chengjun Song1, Zhijun Dong2, Zhejun Su2, Jingfeng Xue1 1Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China 2Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China
In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.
11-5422/R
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Zhihong Chen, Doctor, Professor, Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China
Author contributions: Zhihong Chen was in charge of funds, conceived and designed the study, analyzed data and wrote the manuscript. Yaqiang He analyzed the data. Chengjun Song fed the animals and provided experimental data. Zhijun Dong and Zhejun Su conducted the statistical analysis. Jingfeng Xue conceived and designed the study, revised the manuscript and guided the study.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2012.03.007