Quantitative determination of propildazine in rat plasma by gas-liquid chromatography

A gas-liquid chromatographic method for the evaluation of the new anti-hypertensive drug propildazine (ISF 2123) in rat plasma is described. The procedure involves separation of the drug from plasma by cation-exchange chromatography, subsequent acylation of the dried eluate with heptafluorobutyric a...

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Bibliographic Details
Published inJournal of chromatography Vol. 161; p. 237
Main Authors Ventura, P, Zanol, M, Visconti, M, Pifferi, G
Format Journal Article
LanguageEnglish
Published Netherlands 21.11.1978
Subjects
Animals
Antihypertensive Agents - blood
Chromatography, Gas
Chromatography, Liquid
Hydrazines - blood
Microchemistry
Pyridazines - blood
Rats
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Summary:A gas-liquid chromatographic method for the evaluation of the new anti-hypertensive drug propildazine (ISF 2123) in rat plasma is described. The procedure involves separation of the drug from plasma by cation-exchange chromatography, subsequent acylation of the dried eluate with heptafluorobutyric anhydride and quantitation with electron-capture detection. Propildazine can be determined in concentrations down to ca. 0.4 microgram/ml.
DOI:10.1016/S0021-9673(01)85232-8