Effects of cervical spinal cord stimulation on cerebral blood flow in the rat

• Published in: Journal of neurosurgery Vol. 93; no. 1 Suppl; p. 71
• Main Authors: Sagher, O, Huang, D L
• Format: Journal Article
• Language: English
• Published: United States 01.07.2000
• Subjects: Analysis of Variance; Animals; Blood Flow Velocity - drug effects; Blood Flow Velocity - physiology; Blood Pressure - drug effects; Blood Pressure - physiology; Brain Stem - drug effects; Brain Stem - physiology; Carbon Dioxide - blood; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Electric Stimulation; Electric Stimulation Therapy; Ganglionic Blockers - pharmacology; Hexamethonium - pharmacology; Laser-Doppler Flowmetry; Male; Oxygen - blood; Posterior Horn Cells - physiology; Rats; Rats, Sprague-Dawley; Spinal Cord - drug effects; Spinal Cord - physiology; Spinal Cord - surgery; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - physiology; Vasodilation - drug effects; Vasodilation - physiology; Vasomotor System - drug effects; Vasomotor System - physiology
• ISSN: 0022-3085
• DOI: 10.3171/spi.2000.93.1.0071

Spinal cord stimulation (SCS) is frequently used for the treatment of chronic pain. Although the mechanisms by which SCS alleviates pain are unclear, they are believed to involve changes within the dorsal horn of the spinal cord. Spinal cord stimulation has also been found to cause significant vasodilation in the peripheral vasculature. The mechanisms underlying this effect are thought to involve sympathetic blockade. A rostral vasodilatory effect has also been described, but changes in cerebral blood flow (CBF) have been poorly delineated. Using laser Doppler flowmetry (LDF), the authors examined the effects of cervical SCS on CBF in rats. Cervical SCS was found to result in a significant increase in cortical LDF values (83 +/- 11% [mean +/- standard error of the mean]). The increase in cortical LDF values was not accompanied by a significant increase in systemic blood pressure. Stimulation of the upper cervical spinal cord was more effective in inducing LDF changes than was that of the lower cervical cord. Changes in SDS-induced LDF values were significantly attenuated after spinal cord transection at the cervicomedullary junction and by the administration of the sympathetic blocker hexamethonium. These results indicate that cervical SCS may induce cerebral vasodilation and that this effect may involve indirect effects on vasomotor centers in the brainstem as well as an alteration in sympathetic tone.