Fluoride Concentration from Dental Sealants A Randomized Clinical Trial

• Published in: Journal of dental research Vol. 92; no. 7_suppl; pp. S23 - S28
• Main Authors: Campus, G., Carta, G., Cagetti, M.G., Bossù, M., Sale, S., Cocco, F., Conti, G., Nardone, M., Sanna, G., Strohmenger, L., Lingström, P., Caria, G.P., Congiu, G., Corridone, D., Mastrobernardino, S., Mura, A., Polimeni, A.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.07.2013
• Subjects: Bisphenol A-Glycidyl Methacrylate - chemistry; CARIES; Cariostatic Agents - analysis; Cariostatic Agents - chemistry; Child; clinical trial; community dentistry; Composite Resins - chemistry; dental care for children; Dentistry; DMF Index; Female; FISSURE SEALANTS; fluorides; Fluorides - analysis; Fluorides - chemistry; Follow-Up Studies; Gingival Crevicular Fluid - chemistry; Glass Ionomer Cements - chemistry; GLASS IONOMERS; HEALTH; Humans; Ion-Selective Electrodes; Male; Odontologi; pit and fissure sealants; Pit and Fissure Sealants - chemistry; PLAQUE; RELEASE; Resin Cements - chemistry; RETENTION; RINSE; saliva; Social Class; SURFACES; Viscosity; saliva; clinical trial; pit and fissure sealants; community dentistry; dental care for children; fluorides
• ISSN: 0022-0345; 1544-0591
• DOI: 10.1177/0022034513484329

A randomized clinical trial was performed in schoolchildren (6-7 yrs) to evaluate fluoride concentration in interproximal fluid after the placement of 3 different sealants. The sample consisted of 2,776 children randomly divided: 926 in the high-viscosity Glass-ionomer Cement group (GIC group), 923 in the fluoride Resin-based group (fluoride-RB group), and 927 in the no-fluoride Resin-based group (RB group). In total, 2,640 children completed the trial. Sealants were applied following manufacturer’s instructions. Interproximal fluid samples were collected at baseline and 2, 7, and 21 days after application of sealants, by insertion of a standardized paperpoint into the interproximal mesial space of the sealed tooth for 15 seconds. Fluoride concentration was evaluated by means of a fluoride ion-selective electrode. At 2 days after sealant application, fluoride concentration was significantly higher in GIC and fluoride-RB groups compared with that in the RB group (p < .01). Mean fluoride concentrations after 7 days were 2.54 (SE 0.68) ppm, 0.85 (SE 0.26) ppm, and 0.53 (SE 0.11) ppm for the three groups, respectively. After 21 days, fluoride concentration in the GIC group remained higher than that in the other two groups. High-viscosity GIC sealants increased the fluoride concentrations in interproximal fluid more than did a Resin-based sealant containing fluoride (ClinicalTrials.gov NCT01588210).