Iron overload, free radical damage, and rhesus haemolytic disease

To test the hypothesis that iron overload induces free radical damage in rhesus haemolytic disease (RHD), cord blood plasma of babies with RHD was compared with that of controls matched for gestational age. Babies with RHD had higher ferritin levels, lower latent iron-binding capacity, increased con...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 335; no. 8695; p. 933
Main Authors Berger, H M, Lindeman, J H, van Zoeren-Grobben, D, Houdkamp, E, Schrijver, J, Kanhai, H H
Format Journal Article
LanguageEnglish
Published England 21.04.1990
Subjects
Antioxidants - analysis
Ascorbic Acid - blood
Erythroblastosis, Fetal - blood
Erythroblastosis, Fetal - physiopathology
Evaluation Studies as Topic
Female
Ferritins - blood
Fetal Blood - analysis
Free Radicals
Humans
Infant, Newborn
Iron - blood
Lipid Peroxidation - physiology
Thiobarbiturates - blood
Uric Acid - blood
Vitamin E - blood
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Summary:To test the hypothesis that iron overload induces free radical damage in rhesus haemolytic disease (RHD), cord blood plasma of babies with RHD was compared with that of controls matched for gestational age. Babies with RHD had higher ferritin levels, lower latent iron-binding capacity, increased concentrations of lipid-peroxidation products, and low vitamin C levels. Plasma of 3 RHD babies did not inhibit peroxidation stress. These findings, of iron overload and free radical damage, have implications for treatment of RHD.
ISSN:0140-6736
DOI:10.1016/0140-6736(90)90997-J