SYNTHESIS AND BIOLOGICAL EVALUATION OF NMDI14 DERIVATIVES AS ANTI-MESOTHELIOMA AGENTS

Mesothelioma is a severe tumor formed in pleura and peritoneum, for which no useful molecular-targeting therapy is available. We synthesized several derivatives of NMDI14, which is a reported inhibitor for non -sense mediated mRNA decay, and evaluated the activity of the NMDI14 derivatives as potent...

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Bibliographic Details
Published inHeterocycles Vol. 100; no. 2; pp. 253 - 266
Main Authors Hong Nhung Nguyen, Suzuki, Koya, Kimura, Yasuaki, Hirokawa, Takatsugu, Murakami-Tonami, Yuko, Abe, Hiroshi
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2020
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MESSENGER-RNA DECAY
IDENTIFICATION
PHOSPHORYLATION
COMPLEXES
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Summary:Mesothelioma is a severe tumor formed in pleura and peritoneum, for which no useful molecular-targeting therapy is available. We synthesized several derivatives of NMDI14, which is a reported inhibitor for non -sense mediated mRNA decay, and evaluated the activity of the NMDI14 derivatives as potential anti-mesothelioma agents. Some of the synthesized compounds showed promising activity in terms of cytotoxicity toward mesothelioma model cells and promotion of GASS expression selectively in mesothelioma cells. These results indicate that the NMDI14 derivatives may be useful for further developing clinically effective anti-mesothelioma drugs.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-19-14191