Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy

• Published in: Journal of magnetism and magnetic materials Vol. 277; no. 1; pp. 165 - 174
• Main Authors: Cao, Jinquan, Wang, Yongxian, Yu, Junfeng, Xia, Jiaoyun, Zhang, Chunfu, Yin, Duanzhi, Häfeli, Urs O.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.06.2004; Elsevier Science
• Subjects: Biological and medical sciences; Condensed matter: electronic structure, electrical, magnetic, and optical properties; Exact sciences and technology; Histidine; Magnetic nanoparticles; Magnetic properties and materials; Magnetic properties of nanostructures; Medical sciences; Physics; Radiolabeling; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Rhenium-188; Technology. Biomaterials. Equipments. Material. Instrumentation; Tricarbonyl complex; 75.50.K; Histidine; Rhenium-188; Magnetic nanoparticles; Radiolabeling; Tricarbonyl complex; 87.59.Q; Inorganic compounds; Amines; Radiolabelling; Surface treatments; XRD; Surface analysis; Experimental study; Radiotherapy; Coatings; Nanoparticles; Magnetic particles; Magnetite; Transmission electron microscopy; Synthesis; Transition elements; Iron oxides
• ISSN: 0304-8853
• DOI: 10.1016/j.jmmm.2003.10.022

Magnetite nanoparticles coated with silica were synthesized and characterized by electron microscopic methods (SEM and TEM) and crystal structure analysis (XRD). After surface modification with an amino silane coupling agent, N-[3-(trimethyoxysilyl) propyl]-ethylenediamine (SG-Si900), histidine was covalently linked to the amine group using glutaraldehyde as cross-linker. The magnetic nanoparticles were then radiolabeled with 188Re with a labeling yield of 91.4±0.3% and good stability in vitro. The labeling mechanism is suggested as fac-[ 188Re(CO) 3(H 2O) 3] + core complexed with imidazolyl groups.