Detection of immune complexes on the surface of polymorphonuclear neutrophils

A simple immunohistological test has been developed to detect and to quantitate the presence of immune complexes (IC) on the surface of human polymorphonuclear neutrophils (PMN). The interaction between IC and PMN has been evaluated in several human IC diseases. High amounts of immunoglobulins (Ig)...

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Bibliographic Details
Published inInternational archives of allergy and applied immunology Vol. 58; no. 2; p. 135
Main Authors Camussi, G, Tetta, C, Cappio, F C
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1979
Subjects
Acid Phosphatase - blood
Alkaline Phosphatase - blood
Humans
Immune Complex Diseases - diagnosis
Immune Complex Diseases - immunology
L-Lactate Dehydrogenase - blood
Lupus Erythematosus, Systemic - immunology
Neutrophils - immunology
Phagocytosis
Polyethylene Glycols - blood
Receptors, Antigen, B-Cell
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Summary:A simple immunohistological test has been developed to detect and to quantitate the presence of immune complexes (IC) on the surface of human polymorphonuclear neutrophils (PMN). The interaction between IC and PMN has been evaluated in several human IC diseases. High amounts of immunoglobulins (Ig) and C3 were detected on the PMN surface from these patients. The deposits of Ig and C3 were inversely related to the percentage of membrane-free receptors for Fc and C3.
ISSN:0020-5915
DOI:10.1159/000232185