Formation of N-nitrosomorpholine in isolated rat lungs during nitrogen dioxide ventilation

An isolated rat lung preparation was ventilated with NO2 while being perfused with a medium containing morpholine. After 60 min of ventilation-perfusion, N-nitrosomorpholine was detected in both lung tissue and perfusate.

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Bibliographic Details
Published inCarcinogenesis (New York) Vol. 4; no. 6; p. 777
Main Authors Postlethwait, E M, Mustafa, M G
Format Journal Article
LanguageEnglish
Published England 1983
Subjects
Animals
Lung - drug effects
Lung - metabolism
Male
Nitrogen Dioxide - pharmacology
Nitrosamines - metabolism
Perfusion
Rats
Rats, Inbred Strains
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Summary:An isolated rat lung preparation was ventilated with NO2 while being perfused with a medium containing morpholine. After 60 min of ventilation-perfusion, N-nitrosomorpholine was detected in both lung tissue and perfusate.
ISSN:0143-3334
DOI:10.1093/carcin/4.6.777