Facile Deoxygenation of Hydroxylated Flavonoids by Palladium-Catalysed Reduction of its Triflate Derivatives

An efficient procedure to deoxygenate hydroxy substituted flavonoids, isoflavonoids and related compounds via their trifluoromethanesulfonates is presented. Their reduction with formic acid in the presence of a catalytic amount of palladium acetate, triethylamine and 1,3-bis(diphenylphosphanyl) prop...

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Bibliographic Details
Published inZeitschrift für Naturforschung. B, A journal of chemical sciences Vol. 60; no. 7; pp. 792 - 796
Main Authors Kövér, József, Antus, Sándor
Format Journal Article
LanguageEnglish
Published BERLIN Verlag der Zeitschrift für Naturforschung 01.07.2005
Walter De Gruyter
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Flavonoids
Palladium(II) Acetate
Physical Sciences
Reduction
Science & Technology
REARRANGEMENT
palladium(II) acetate
ISOFLAVONES
ACID
ANALOGS
CHROMONES
PHENOLS
EFFICIENT SYNTHESIS
PRECOCENES
PTEROCARPANS
flavonoids
reduction
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Summary:An efficient procedure to deoxygenate hydroxy substituted flavonoids, isoflavonoids and related compounds via their trifluoromethanesulfonates is presented. Their reduction with formic acid in the presence of a catalytic amount of palladium acetate, triethylamine and 1,3-bis(diphenylphosphanyl) propane (dppp) in DMF results in their des-hydroxy derivatives without affecting other functional groups.
ISSN:0932-0776
1865-7117
DOI:10.1515/znb-2005-0716