Clinical outcomes of horizontal ridge augmentation using indigenous prepared FDBA and amnion chorion membrane—a clinical study

• Published in: Cell and tissue banking Vol. 26; no. 3; p. 33
• Main Authors: Oriya, Bhawana, Faraz, Farrukh, Lamba, Arundeep Kaur, Tandon, Shruti, Datta, Archita, Dhingra, Sachin
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 02.08.2025; Springer Nature B.V
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; AIDS; Allografts; Alveolar Ridge Augmentation - methods; Amnion; Amnion - transplantation; Biomedical and Life Sciences; Biomedicine; Bone grafts; Bone Transplantation - methods; Cell Biology; Chorion; Chorion - transplantation; Cytomegalovirus; Epstein-Barr virus; Female; Full Length Paper; HIV; Human immunodeficiency virus; Humans; Life Sciences; Male; Middle Aged; Prospective Studies; Transplant Surgery; Treatment Outcome; Young Adult; Malaysia; Alveolar ridge augmentation; Amnion-chorion membrane; Allograft; Bone graft
• ISSN: 1573-6814; 1389-9333; 1573-6814
• DOI: 10.1007/s10561-025-10184-1

A prospective clinical study was conducted to evaluate the change in horizontal alveolar ridge width following horizontal ridge augmentation using Freeze-Dried Bone Allograft (FDBA) block graft and Amnion Chorion Membrane (ACM) for the management of atrophic ridges. The study included a total of 10 subjects of either sex, aged between 18 and 60 years, presenting with deficient residual alveolar ridge width. All subjects were treated with horizontal ridge augmentation using an indigenously prepared FDBA block graft and ACM. The ridge width at the alveolar crest and 5 mm apical to the crest were recorded at baseline, immediately after augmentation, and after 6 months, followed by dental implant placement. Also, this study focused on the clinical efficacy and any adverse effects of the indigenously prepared FDBA block graft and ACM. The indigenously prepared FDBA block graft and ACM exhibit regenerative properties that significantly enhance horizontal alveolar ridge width in all cases of deficient ridges, thereby greatly facilitating dental implant placement. The mean difference after 6 months at the crest was 2.21 ± 0.89 mm (p < 0.05) and at 5 mm apical to the crest was 2.8 ± 0.91 mm (p = 0.001)This significant increase in ridge width achieved through indigenously prepared FDBA and ACM serves as an excellent alternative to commercially sourced or imported allograft materials, making it a cost-efficient choice.