Prostaglandin E 2 as a Regulator of Immunity to Pathogens

The body is exposed to foreign pathogens every day, but remarkably, most pathogens are effectively cleared by the innate immune system without the need to invoke the adaptive immune response. Key cellular components of the innate immune system include macrophages and neutrophils and the recruitment...

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Bibliographic Details
Published inPharmacology & therapeutics (Oxford) Vol. 185; pp. 135 - 146
Main Authors Martínez-Colón, Giovanny J, Moore, Bethany B
Format Journal Article
LanguageEnglish
Published England 01.05.2018
Subjects
Adaptive Immunity
Animals
Autophagy
Dinoprostone - immunology
Dinoprostone - metabolism
Extracellular Traps - immunology
Humans
Immunity, Innate
Infections - immunology
Interleukin-1beta - immunology
Toll-Like Receptors - immunology
eicosanoids
pathogen
innate immunity
inflammation
adaptive immunity
host defense
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Summary:The body is exposed to foreign pathogens every day, but remarkably, most pathogens are effectively cleared by the innate immune system without the need to invoke the adaptive immune response. Key cellular components of the innate immune system include macrophages and neutrophils and the recruitment and function of these cells are tightly regulated by chemokines and cytokines in the tissue space. Innate immune responses are also known to regulate development of adaptive immune responses often via the secretion of various cytokines. In addition to these protein regulators, numerous lipid mediators can also influence innate and adaptive immune functions. In this review, we cover one particular lipid regulator, prostaglandin E (PGE ) and describe its synthesis and signaling and what is known about the ability of this lipid to regulate immunity and host defense against viral, fungal and bacterial pathogens.
ISSN:0163-7258
1879-016X
DOI:10.1016/j.pharmthera.2017.12.008