Functional polymer – clay nanotube biocomposites with sustained drug release

By adding 5% (w/w) of halloysite nanotubes that have been modified (loaded) with proteins or drugs it is possible to produce strong and functional biocomposites. Materials loaded with both types of materials were investigated using ultraviolet-visible spectrophotometry and thermogravimetric analysis...

Full description

Saved in:
Bibliographic Details
Published inIOP conference series. Materials Science and Engineering Vol. 64; no. 1; p. 12032
Main Authors Lvov, Y, Tully, J
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 22.08.2014
Subjects
Antibiotics
Biomedical materials
Composite materials
Nanotubes
Proteins
Spectrophotometry
Sustained release
Thermogravimetric analysis
Online AccessGet full text

Cover

More Information
Summary:By adding 5% (w/w) of halloysite nanotubes that have been modified (loaded) with proteins or drugs it is possible to produce strong and functional biocomposites. Materials loaded with both types of materials were investigated using ultraviolet-visible spectrophotometry and thermogravimetric analysis to determine their release kinetics and overall loading efficiency. It was found that both released over a period of 5-20 hours with two distinct phases being present. An initial "burst stage" of release followed by a period of sustained release. Specifically, for proteins it has been shown that a significant amount (50-75%) remain immobilized even after being dispersed. The typical loading efficiency for both classes of molecules was 10-15%. These modified nanotubes can both strengthen a material and give it unique functionality and possible uses include more effective externally applied antibiotics and immobilized proteins with enhanced stability and reusability.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/64/1/012032