Proteinuria in newly diagnosed type II diabetic patients
Proteinuria in newly diagnosed type II diabetic patients. M Uusitupa , O Siitonen , I Penttilä , A Aro and K Pyörälä Abstract Urinary excretion of albumin, IgG, and beta 2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged type II diabetic patients and in 144 (62 men,...
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Published in | Diabetes care Vol. 10; no. 2; pp. 191 - 194 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Diabetes Association
01.03.1987
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Abstract | Proteinuria in newly diagnosed type II diabetic patients.
M Uusitupa ,
O Siitonen ,
I Penttilä ,
A Aro and
K Pyörälä
Abstract
Urinary excretion of albumin, IgG, and beta 2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged
type II diabetic patients and in 144 (62 men, 82 women) nondiabetic control subjects. Both male (N = 57) and female (N = 29)
diabetic patients with normal urinary sediment showed an increased excretion of albumin compared with the respective nondiabetic
subjects, and male diabetic patients also had an increased IgG excretion. No consistent difference was found in urinary beta
2-microglobulin concentration between the diabetic and nondiabetic subjects. In all, 19.5% of the diabetic subjects with normal
urinary sediment (12 men, 5 women) showed urinary albumin concentration exceeding the highest value (35 mg/24 h) found in
nondiabetic subjects without renal disease. The urinary excretion of albumin in the diabetic subjects was not associated with
the presence of hypertension or coronary heart disease or with the fasting blood glucose or serum insulin levels measured
at diagnosis of diabetes. In male diabetic subjects with urinary albumin excretion greater than 35 mg/24 h, a reduced creatinine
clearance was found, suggesting the presence of structural damage associated with diabetic nephropathy. The early increase
of urinary albumin excretion in type II diabetic patients may be mostly functional in nature. However, some patients may have
structural renal damage associated with diabetic nephropathy present at diagnosis. |
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AbstractList | Proteinuria in newly diagnosed type II diabetic patients.
M Uusitupa ,
O Siitonen ,
I Penttilä ,
A Aro and
K Pyörälä
Abstract
Urinary excretion of albumin, IgG, and beta 2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged
type II diabetic patients and in 144 (62 men, 82 women) nondiabetic control subjects. Both male (N = 57) and female (N = 29)
diabetic patients with normal urinary sediment showed an increased excretion of albumin compared with the respective nondiabetic
subjects, and male diabetic patients also had an increased IgG excretion. No consistent difference was found in urinary beta
2-microglobulin concentration between the diabetic and nondiabetic subjects. In all, 19.5% of the diabetic subjects with normal
urinary sediment (12 men, 5 women) showed urinary albumin concentration exceeding the highest value (35 mg/24 h) found in
nondiabetic subjects without renal disease. The urinary excretion of albumin in the diabetic subjects was not associated with
the presence of hypertension or coronary heart disease or with the fasting blood glucose or serum insulin levels measured
at diagnosis of diabetes. In male diabetic subjects with urinary albumin excretion greater than 35 mg/24 h, a reduced creatinine
clearance was found, suggesting the presence of structural damage associated with diabetic nephropathy. The early increase
of urinary albumin excretion in type II diabetic patients may be mostly functional in nature. However, some patients may have
structural renal damage associated with diabetic nephropathy present at diagnosis. Urinary excretion of albumin, IgG, and β2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged type II diabetic patients and in 144 (62 men, 82 women) nondiabetic control subjects. Both male (N = 57) and female (N = 29)diabetic patients with normal urinary sediment showed an increased excretion of albumin compared with the respective nondiabetic subjects, and male diabetic patients also had an increased IgG excretion. No consistent difference was found in urinary (β2-microglobulin concentration between the diabetic and nondiabetic subjects. In all, 19.5% of the diabetic subjects with normal urinary sediment (12 men, 5 women) showed urinary albumin concentration exceeding the highest value (35 mg/24 h) found in nondiabetic subjects without renal disease. The urinary excretion of albumin in the diabetic subjects was not associated with the presence of hypertension or coronary heart disease or with thefasting blood glucose or serum insulin levels measured at diagnosis of diabetes. In male diabetic subjects with urinary albumin excretion >35 mg/ 24 h, a reduced creatinine clearance was found, suggesting the presence of structural damage associated with diabetic nephropathy. The early increase of urinary albumin excretion in type II diabetic patients may be mostly functional in nature. However, some patients may have structural renaldamage associated with diabetic nephropathy present at diagnosis. Urinary excretion of albumin, IgG, and beta 2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged type II diabetic patients and in 144 (62 men, 82 women) nondiabetic control subjects. Both male (N = 57) and female (N = 29) diabetic patients with normal urinary sediment showed an increased excretion of albumin compared with the respective nondiabetic subjects, and male diabetic patients also had an increased IgG excretion. No consistent difference was found in urinary beta 2-microglobulin concentration between the diabetic and nondiabetic subjects. In all, 19.5% of the diabetic subjects with normal urinary sediment (12 men, 5 women) showed urinary albumin concentration exceeding the highest value (35 mg/24 h) found in nondiabetic subjects without renal disease. The urinary excretion of albumin in the diabetic subjects was not associated with the presence of hypertension or coronary heart disease or with the fasting blood glucose or serum insulin levels measured at diagnosis of diabetes. In male diabetic subjects with urinary albumin excretion greater than 35 mg/24 h, a reduced creatinine clearance was found, suggesting the presence of structural damage associated with diabetic nephropathy. The early increase of urinary albumin excretion in type II diabetic patients may be mostly functional in nature. However, some patients may have structural renal damage associated with diabetic nephropathy present at diagnosis. |
Author | O Siitonen K Pyörälä A Aro M Uusitupa I Penttilä |
Author_xml | – sequence: 1 givenname: Matti surname: Uusitupa fullname: Uusitupa, Matti organization: Departments of Medicine, Kuopio University Central Hospital Kuopio, Finland – sequence: 2 givenname: Onni surname: Siitonen fullname: Siitonen, Onni organization: Departments of Medicine, Kuopio University Central Hospital Kuopio, Finland – sequence: 3 givenname: Ilkka surname: Penttilä fullname: Penttilä, Ilkka organization: Clinical Chemistry, Kuopio University Central Hospital Kuopio, Finland – sequence: 4 givenname: Antti surname: Aro fullname: Aro, Antti organization: Departments of Medicine, Kuopio University Central Hospital Kuopio, Finland – sequence: 5 givenname: Kalevi surname: Pyörälä fullname: Pyörälä, Kalevi organization: Departments of Medicine, Kuopio University Central Hospital Kuopio, Finland |
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Snippet | Proteinuria in newly diagnosed type II diabetic patients.
M Uusitupa ,
O Siitonen ,
I Penttilä ,
A Aro and
K Pyörälä
Abstract
Urinary excretion of albumin,... Urinary excretion of albumin, IgG, and beta 2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged type II diabetic patients and... Urinary excretion of albumin, IgG, and β2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged type II diabetic patients and in... |
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SubjectTerms | beta 2-Microglobulin - urine Blood Glucose - analysis Creatinine - blood Creatinine - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Female Humans Immunoglobulin G - urine Male Middle Aged Proteinuria - complications |
Title | Proteinuria in newly diagnosed type II diabetic patients |
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