Proteinuria in newly diagnosed type II diabetic patients
Proteinuria in newly diagnosed type II diabetic patients. M Uusitupa , O Siitonen , I Penttilä , A Aro and K Pyörälä Abstract Urinary excretion of albumin, IgG, and beta 2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged type II diabetic patients and in 144 (62 men,...
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Published in | Diabetes care Vol. 10; no. 2; pp. 191 - 194 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Diabetes Association
01.03.1987
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Subjects | |
Online Access | Get full text |
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Summary: | Proteinuria in newly diagnosed type II diabetic patients.
M Uusitupa ,
O Siitonen ,
I Penttilä ,
A Aro and
K Pyörälä
Abstract
Urinary excretion of albumin, IgG, and beta 2-microglobulin was examined in 132 (69 men, 63 women) newly diagnosed, middle-aged
type II diabetic patients and in 144 (62 men, 82 women) nondiabetic control subjects. Both male (N = 57) and female (N = 29)
diabetic patients with normal urinary sediment showed an increased excretion of albumin compared with the respective nondiabetic
subjects, and male diabetic patients also had an increased IgG excretion. No consistent difference was found in urinary beta
2-microglobulin concentration between the diabetic and nondiabetic subjects. In all, 19.5% of the diabetic subjects with normal
urinary sediment (12 men, 5 women) showed urinary albumin concentration exceeding the highest value (35 mg/24 h) found in
nondiabetic subjects without renal disease. The urinary excretion of albumin in the diabetic subjects was not associated with
the presence of hypertension or coronary heart disease or with the fasting blood glucose or serum insulin levels measured
at diagnosis of diabetes. In male diabetic subjects with urinary albumin excretion greater than 35 mg/24 h, a reduced creatinine
clearance was found, suggesting the presence of structural damage associated with diabetic nephropathy. The early increase
of urinary albumin excretion in type II diabetic patients may be mostly functional in nature. However, some patients may have
structural renal damage associated with diabetic nephropathy present at diagnosis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0149-5992 1935-5548 |
DOI: | 10.2337/diacare.10.2.191 |