Bet v 1- and Bet v 2-Associated Plant Food Sensitization in Uganda and Germany: Differences and Similarities

• Published in: International archives of allergy and immunology Vol. 167; no. 4; pp. 264 - 269
• Main Authors: Odongo, Leo, Mulyowa, Grace, Goebeler, Matthias, Trautmann, Axel
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2015
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Allergens - adverse effects; Alnus acuminata; Antibody Specificity; Antigens, Plant - adverse effects; Antigens, Plant - immunology; Arachis hypogaea; Atopic dermatitis; Betula; Betulaceae; Birches; Child; Child, Preschool; Composition; Corylus; Cross Reactions; Female; Food hypersensitivity; Food Hypersensitivity - epidemiology; Food Hypersensitivity - etiology; Food Hypersensitivity - immunology; Germany - epidemiology; Health aspects; Humans; Hypersensitivity, Immediate - epidemiology; Hypersensitivity, Immediate - etiology; Hypersensitivity, Immediate - immunology; Immunoglobulin E - blood; Male; Malus; Middle Aged; Original Paper; Plant products; Pollen; Prevalence; Prospective Studies; Prunus; Rhinitis, Allergic, Seasonal - complications; Rhinitis, Allergic, Seasonal - epidemiology; Rhinitis, Allergic, Seasonal - immunology; Risk factors; Uganda - epidemiology; Young Adult; Uganda; Germany; Food allergy; Alder pollen; Pollen allergy; Birch pollen; Africa; Atopy
• ISSN: 1018-2438; 1423-0097
• DOI: 10.1159/000439533

Background: Birch pollen allergy and concomitant plant food sensitization are well documented in Europe. However, there are currently no data available on pollen-associated plant food sensitization or even pollen allergy in tropical Africa. Our study aimed to investigate Bet v 1- and Bet v 2-associated plant food sensitization in atopic patients from Uganda and compare it with sensitization rates in German patients. Methods: Sera from 83 Ugandan and 97 German atopic patients were analysed using UniCAP100™ for allergen-specific IgE against the birch tree pollen allergens Bet v 1 and Bet v 2 as well as the plant foods hazelnut, apple, kiwi, pea, peach, cherry, litchi, peanut, and soy. Results: As expected, sensitization to Bet v 1 and cross-reactive plant food allergens was more common in German atopic patients. In contrast, the prevalence of sensitization against Bet v 2 was remarkably similar in Ugandan and German patients. Interestingly, in Ugandan patients we found IgE-mediated sensitization against plant foods such as hazelnut, pea, peach, cherry, and litchi that are neither cultivated nor consumed in Uganda. Conclusions: For Ugandan atopic patients, sensitization against the Bet v 2 allergen (a plant profilin) may explain cross-reactivity to several plant foods which are not consumed in Uganda. Additionally, it is probable that sensitization of Ugandan atopics to alder pollen (Alnus acuminata, plant family Betulaceae) caused serological cross-reactivity with Betula verrucosa-related allergens.