Sciatic nerve regeneration across gaps within collagen chambers: the influence of epidermal growth factor

The effects of Epidermal Growth Factor (EGF) on axonal regeneration of a sectioned sciatic nerve within collagen tubes were investigated in 15 rats. Following baseline electrophysiologic assessment, bilateral 7-mm nerve gaps were created and repaired by interposition of collagen tubes, into which EG...

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Bibliographic Details
Published inJournal of reconstructive microsurgery Vol. 9; no. 5; p. 341
Main Authors Dubuisson, A S, Beuermann, R W, Kline, D G
Format Journal Article
LanguageEnglish
Published United States 01.09.1993
Subjects
Action Potentials
Animals
Collagen
Epidermal Growth Factor - pharmacology
Nerve Regeneration
Neural Conduction
Prostheses and Implants
Rats
Rats, Sprague-Dawley
Sciatic Nerve - injuries
Sciatic Nerve - pathology
Sciatic Nerve - physiology
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Summary:The effects of Epidermal Growth Factor (EGF) on axonal regeneration of a sectioned sciatic nerve within collagen tubes were investigated in 15 rats. Following baseline electrophysiologic assessment, bilateral 7-mm nerve gaps were created and repaired by interposition of collagen tubes, into which EGF (left side) or type I collagen (right side) was instilled. After 4 or 8 weeks, axonal regeneration, measured by electrophysiologic and histologic means, was identical for the EGF and control legs. The conclusion is that EGF does not influence nerve regeneration within a collagen chamber.
ISSN:0743-684X
DOI:10.1055/s-2007-1006741