Inflammatory response in on- versus off-pump myocardial revascularization: is ECC really the culprit?

A review of inflammatory mediators in on- versus off-pump surgery reveals that parameters of systemic inflammation differ quantitatively, not qualitatively between these approaches. Mediator system and cellular activation is observed after surgical trauma and following ischemia/reperfusion. Such act...

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Bibliographic Details
Published inThe Thoracic and cardiovascular surgeon Vol. 55; no. 8; p. 473
Main Authors Börgermann, J, Scheubel, R J, Simm, A, Silber, R E, Friedrich, I
Format Journal Article
LanguageEnglish
Published Germany 01.12.2007
Subjects
Complement Activation
Coronary Artery Bypass, Off-Pump - adverse effects
Coronary Artery Bypass, Off-Pump - methods
Cytokines - metabolism
Extracorporeal Circulation - adverse effects
Extracorporeal Circulation - methods
Humans
Immunity, Cellular - physiology
Inflammation
Myocardial Ischemia - surgery
Myocardial Revascularization
Oxidative Stress - physiology
Risk Factors
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Summary:A review of inflammatory mediators in on- versus off-pump surgery reveals that parameters of systemic inflammation differ quantitatively, not qualitatively between these approaches. Mediator system and cellular activation is observed after surgical trauma and following ischemia/reperfusion. Such activation is also modulated by genetic factors. The available literature does not permit definitive conclusions to be made on the advantages of off-pump surgery with respect to the systemic inflammatory response. The relationship between mediator systems and clinical course needs to be assessed in large patient populations to demonstrate to what extent off-pump surgery is more than just theoretically superior to on-pump surgery.
ISSN:0171-6425
DOI:10.1055/s-2007-965631