Do ovarian reserve markers predict the subsequent pregnancy outcomes in women with recurrent pregnancy loss?

• Published in: Turkish Journal of Biochemistry Vol. 43; no. 5; pp. 481 - 486
• Main Authors: Yildirim, Gonca Yetkin, Celik, Hale Goksever, Koroglu, Nadiye, Karakus, Esra
• Format: Journal Article
• Language: English
• Published: De Gruyter 01.10.2018
• Subjects: Antimullerian hormone; Antimülleryan hormon; Antral folikül sayısı; Antral follicle count; Folikül stimuli edici hormone; Follicle stimulating hormone; Ovarian reserve; Over rezervi; Recurrent pregnancy loss; Tekrarlayan gebelik kaybı
• ISSN: 0250-4685; 1303-829X
• DOI: 10.1515/tjb-2017-0238

Abstract Objective(s) Chromosomal abnormalities are more commonly seen in embryos with decreased oocyte quality. Therefore aneuploidy due to diminished ovarian reserve may be one of the causative reasons of RPL. We investigated the relationship between ovarian reserve markers especially serum antimullerian hormone (AMH) level and antral follicle count (AFC) and recurrent pregnancy loss (RPL). Materials and methods This prospective cross-sectional clinical trial including 88 women with RPL and 84 age-matched women without RPL. Results There were statistically significant differences in body mass index, live birth number, menstrual cycle length, AFC and serum AMH level between groups. There was no statistically significant difference between groups regarding age, menstrual cycle regularity and serum follicle stimulating hormone (FSH) and estradiol (E 2 ) levels. The percentage of women with levels of AMH<1 was 21.4% in the RPL group and 11.4% in the control group. AFC <7 in both ovaries was lower in the RPL group when compared with the control group (73.8% vs 44.3%, respectively). Conclusion(s) Serum AMH levels and AFC can be assessed in patients with RPL as a part of the work up parameters. Lower Serum AMH levels and AFC especially may predict the quantity of oocytes that may be consequently be related with RPL.