Mandibular third molar development after mantle radiation in long-term survivors of childhood Hodgkin's disease

• Published in: Oral surgery, oral medicine, oral pathology Vol. 63; no. 5; pp. 630 - 633
• Main Authors: McGinnis, J.Perry, Hopkins, Kenneth P., Thompson, Elizabeth I., Hustu, H.Omar
• Format: Journal Article
• Language: English
• Published: Saint Louis, MO Elsevier Inc 01.05.1987; Mosby
• Subjects: Abnormalities, Radiation-Induced - etiology; Adolescent; Adult; Anodontia - etiology; Biological and medical sciences; Child; Child, Preschool; Female; Follow-Up Studies; Hematologic and hematopoietic diseases; Hodgkin Disease - radiotherapy; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Mandible; Medical sciences; Molar, Third - abnormalities; Molar, Third - radiation effects; Odontogenesis - radiation effects; Human; Agenesis; Radiodiagnosis; Stomatology; Complication; Hodgkin disease; Mantle field radiotherapy; Hemopathy; Tooth; Child; Long term; Survival
• ISSN: 0030-4220; 1878-2175
• DOI: 10.1016/0030-4220(87)90242-8

Sequential panoramic radiographs were assessed for mandibular third molar development in 47 long-term survivors of childhood Hodgkin's disease after treatment with 37 Gy mantle field radiation. To make a comparison, panoramic radiographs of 149 healthy, nonirradiated children were reviewed for the presence of mandibular third molars. In children between the ages of 7 and 12 years, bilateral agenesis of mandibular third molars was more frequent in patients who had been treated with mantle radiation than in nonirradiated patients. Unilateral agenesis, crown hypoplasia, and root growth impairment of mandibular third molars were also found. Similar, apparent, radiation-induced developmental anomalies were noted in maxillary third molars of the irradiated patients.