Treatment of thrombotic thrombocytopenic purpura

The review discusses approaches to treatment of acquired thrombotic thrombocytopenic purpuгa (aTTP). In patients with aTTP plasma exchanges, glucocorticosteroids allow to stop an acute attack of TTP, and use of rituximab allows to achieve remission. In recent years, caplacizumab has been used. Treat...

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Published inTerapevtic̆eskii arhiv Vol. 93; no. 6; pp. 736 - 745
Main Authors Galstyan, G M, Maschan, A A, Klebanova, E E, Kalinina, I I
Format Journal Article
LanguageRussian
English
Published Russia (Federation) "Consilium Medicum" Publishing house 15.06.2021
Subjects
Acetylcysteine
adamts13
Bortezomib
caplacizumab
Child
Cyclosporine
cyclosporine a
Humans
n-acetylcysteine
Plasma Exchange
pregnancy
Purpura, Thrombotic Thrombocytopenic - diagnosis
Purpura, Thrombotic Thrombocytopenic - drug therapy
recombinant adamts13
rituximab
Rituximab - therapeutic use
therapeutic plasma exchange
thrombotic thrombocytopenic purpura
ADAMTS13
cyclosporine A
recombinant ADAMTS13
caplacizumab
pregnancy
therapeutic plasma exchange
thrombotic thrombocytopenic purpura
bortezomib
rituximab
N-acetylcysteine
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Summary:The review discusses approaches to treatment of acquired thrombotic thrombocytopenic purpuгa (aTTP). In patients with aTTP plasma exchanges, glucocorticosteroids allow to stop an acute attack of TTP, and use of rituximab allows to achieve remission. In recent years, caplacizumab has been used. Treatment options such as cyclosporin A, bortezomib, splenectomy, N-acetylcysteine, recombinant ADAMTS13 are also described. Separately discussed issues of management of patients with TTP during pregnancy, and pediatric patients with TTP.
ISSN:0040-3660
2309-5342
DOI:10.26442/00403660.2021.06.200894