The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp No. 00144 - III. Structure determination

A novel gluconeogenesis inhibitor, FR225654 was isolated from the culture broth of Phoma sp. No. 00144. Spectroscopic analysis concluded that FR225654 has a highly oxygenated trans-decalin ring and beta-keto-enol in its main part, and has a characteristic side chain possessing a conjugated carboxyli...

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Bibliographic Details
Published inJournal of antibiotics Vol. 58; no. 7; pp. 479 - 482
Main Authors Ohtsu, Y, Yoshimura, S, Kinoshita, T, Takase, S, Nakajima, H
Format Journal Article
LanguageEnglish
Published TOKYO Japan Antibiotics Research Assoc 01.07.2005
Subjects
Biotechnology & Applied Microbiology
Gluconeogenesis - drug effects
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Immunology
Life Sciences & Biomedicine
Microbiology
Molecular Structure
Naphthalenes - chemistry
Naphthalenes - isolation & purification
Naphthalenes - pharmacology
Pharmacology & Pharmacy
Phoma
Science & Technology
Stereoisomerism
Structure-Activity Relationship
FR225654
hepatocyte
gluconeogenesis
diabetes
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Summary:A novel gluconeogenesis inhibitor, FR225654 was isolated from the culture broth of Phoma sp. No. 00144. Spectroscopic analysis concluded that FR225654 has a highly oxygenated trans-decalin ring and beta-keto-enol in its main part, and has a characteristic side chain possessing a conjugated carboxylic acid and tri-substituted olefin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2005.64