Novel role of microRNAs in prostate cancer

• Published in: Chinese medical journal Vol. 126; no. 15; pp. 2960 - 2964
• Main Authors: Yu, Jun-jie, Xia, Shu-jie
• Format: Journal Article
• Language: English
• Published: China Department of Urology, First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China 2013
• Subjects: Biomarkers - analysis; Drug Resistance, Neoplasm; Humans; Male; microRNA; MicroRNAs - analysis; MicroRNAs - physiology; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; 前列腺癌; 小分子RNA; 独立变换; 生物标志物; 细胞分化; 能量代谢; 药物敏感性; microRNA; prostate cancer; biomarkers
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20122649

Objective To discuss the novel biomarkers of microRNAs in prostate cancer. Date sources The literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012. Study selection Original articles regarding the novel role of microRNAs in prostate cancer were selected. Results MicroRNAs play an important role in prostate cancer such as cell differentiation, proliferation, apoptosis, and invasion. Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition （EMT）, cancer stem cells （CSCs）, drug sensitivity, cancer microenvironment, energy metabolism, androgen independence transformation, and diagnosis prediction. Conclusions MicroRNAs are involved in various aspects of prostate cancer biology. The role of microRNA in the initiation and development of prostate cancer deserves further study.