Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic beta-cells via AMPK activation

• Published in: Chemical communications (Cambridge, England) Vol. 50; no. 76; pp. 11222 - 11225
• Main Authors: Pasternak, L., Meltzer-Mats, E., Babai-Shani, G., Cohen, G., Viskind, O., Eckel, J., Cerasi, E., Sasson, S., Gruzman, A.
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 04.10.2014
• Subjects: AMP-Activated Protein Kinases - metabolism; Animals; Benzothiazoles - chemistry; Benzothiazoles - pharmacology; Cell Line; Chemistry; Chemistry, Multidisciplinary; Enzyme Activation - drug effects; Glucose - metabolism; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - enzymology; Insulin-Secreting Cells - metabolism; Muscle, Skeletal - cytology; Muscle, Skeletal - drug effects; Physical Sciences; Rats; Science & Technology; AICAR; EXPRESSION; PROTEIN-KINASE; RAT ADIPOCYTES; SUBUNIT
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c4cc03310h

Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E beta-cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs.