Study of peptides inhibiting the angiotensin-converting enzyme of human seminal plasma

Several peptides were investigated for their inhibitory capacity against dipeptidyl carboxypeptidase (angiotensin-converting enzyme) from human seminal fluid. The strongest inhibitor was the nonapeptide SQ 20881. A marked inhibition was also shown by the compounds Phe-Ala-Pro and Boc-Phe-Ala-Pro, wh...

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Bibliographic Details
Published inEnzyme (Basel) Vol. 24; no. 6; p. 362
Main Authors Depierre, D, Bargetzi, J P, Roth, M
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1979
Subjects
Angiotensin II - metabolism
Angiotensin III - metabolism
Angiotensin-Converting Enzyme Inhibitors
Humans
Lung - enzymology
Male
Oligopeptides - pharmacology
Semen - enzymology
Teprotide - pharmacology
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Summary:Several peptides were investigated for their inhibitory capacity against dipeptidyl carboxypeptidase (angiotensin-converting enzyme) from human seminal fluid. The strongest inhibitor was the nonapeptide SQ 20881. A marked inhibition was also shown by the compounds Phe-Ala-Pro and Boc-Phe-Ala-Pro, which behaved as competitive inhibitors. Among the peptides related to angiotensin, angiotensin III was the strongest inhibitor, followed by angiotensin II and the C-terminal hexapeptide of angiotensin II. The results indicate the dipeptidyl carboxypeptidase of human semen is very similar to pulmonary dipeptidyl carboxypeptidase in its susceptibility to peptide inhibitors. In view of these and other previously reported similarities, it is possible that both enzymes are identical.
ISSN:0013-9432
DOI:10.1159/000458691