Magnetic resonance imaging evaluation of Yukatan minipig brains for neurotherapy applications

• Published in: Laboratory animal research Vol. 27; no. 4; pp. 309 - 316
• Main Authors: Yun, S.P., Chonnam National University, Gwangju, Republic of Korea, Kim, D.H., Chosun University Hospital, Gwangju, Republic of Korea, Ryu, J.M., Chonnam National University, Gwangju, Republic of Korea, Park, J.H., Chonnam National University, Gwangju, Republic of Korea, Park, S.S., Chonnam National University, Gwangju, Republic of Korea, Jeon, J.H., Chonnam National University, Gwangju, Republic of Korea, Seo, B.N., Chonnam National University, Gwangju, Republic of Korea, Kim, H.J., Chonnam National University, Gwangju, Republic of Korea, Park, J.G., Chonnam National University, Gwangju, Republic of Korea, Cho, K.O., Chonnam National University, Gwangju, Republic of Korea, Han, H.J., Seoul National University, Seoul, Republic of Korea
• Format: Journal Article
• Language: English
• Published: England 한국실험동물학회 01.12.2011; Korean Association for Laboratory Animal Science
• Subjects: BRAIN; CEREBRO; ENCEPHALE; magnetic resonance imaging; neurologic disorder; Original; Yukatan minipigs; 수의학; neurologic disorder; Brain; magnetic resonance imaging; Yukatan minipigs
• ISSN: 1738-6055; 2233-7660
• DOI: 10.5625/lar.2011.27.4.309

Magnetic resonance imaging (MRI) of six Yukatan minipig brains was performed. The animals were placed in stereotaxic conditions currently used in experiments. To allow for correctpositioning of the animal in the MRI instrument, landmarks were previously traced on the snout of the pig. To avoid movements, animal were anesthetized. The animals were placed in a prone position in a Siemens Magnetom Avanto 1.5 System with a head coil. Axial T2-weighted and sagittal T1-weighted MRI images were obtained from each pig. Afterwards, the brains of the pigs were fixed and cut into axial sections. Histologic and MR images were compared. The usefulness of this technique is discussed.