Flavonoids From the Aerial Parts of Sophora tonkinensis and Their Potential Anti‐Inflammatory Activities

• Published in: Chemistry & biodiversity Vol. 21; no. 6; pp. e202400399 - n/a
• Main Authors: Yang, Qing‐Qing, Yang, Yan‐Fei, Chen, Xuan‐Qin, Li, Rong‐Tao, Zhang, Zhi‐Jun
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.06.2024
• Subjects: Anti-inflammatory; Flavonoids; Inflammation; Leguminosae; Lipopolysaccharides; Magnetic resonance spectroscopy; Mass spectrometry; Mass spectroscopy; Nitric oxide; NMR spectroscopy; NO production inhibitory Activity; Prenylated flavonoids; Sophora tonkinensis; Leguminosae; Prenylated flavonoids; Anti-inflammatory; Sophora tonkinensis; NO production inhibitory Activity
• ISSN: 1612-1872; 1612-1880; 1612-1880
• DOI: 10.1002/cbdv.202400399

Four undescribed prenylated flavonoids, sophoratones A–D (1–4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and ECD calculations. Meanwhile, the ability of these compounds to inhibit the release of nitric oxide (NO) by a lipopolysaccharide induced mouse in RAW 264.7 cells was assayed. The results indicated that some compounds exhibited clear inhibitory effects, with IC50 ranging from 19.91±1.08 to 35.72±2.92 μM. These results suggest that prenylated flavonoids from the aerial parts of S. tonkinensis could potentially be used as a latent source of anti‐inflammatory agents.