Germacrane‐Type Sesquiterpene Lactones from Achillea millefolium L. and Their Anti‐Inflammatory Activity

• Published in: Chemistry & biodiversity Vol. 20; no. 4; pp. e202300079 - n/a
• Main Authors: Li, Hongliang, Akber Aisa, Haji, Li, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.04.2023
• Subjects: Acetic acid; Achillea - chemistry; Achillea millefolium; Achillea millefolium L; anti-inflammatory activity; Anti-inflammatory agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Asteraceae; Circular dichroism; Dichroism; Ethyl acetate; germacrane-type sesquiterpene lactones; Inflammation; Lactones; Lactones - chemistry; Lactones - pharmacology; Lipopolysaccharides; Mathematical analysis; Molecular Structure; Nitric oxide; NMR; Nuclear magnetic resonance; Sesquiterpene lactones; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; Sesquiterpenes, Germacrane - chemistry; Sesquiterpenes, Germacrane - pharmacology; germacrane-type sesquiterpene lactones; Asteraceae; Achillea millefolium L; anti-inflammatory activity
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202300079

Six undescribed germacrane‐type sesquiterpene lactones, millefoliumons A–F, and two known analogs were isolated from the ethyl acetate fraction of the whole plant of Achillea millefolium L. growing in Xinjiang, China. The structures of these compounds were fully elucidated by their 1D and 2D nuclear magnetic resonance (NMR), and high resolution mass (HR‐ESI‐MS) spectral data, and comparison with literatures. The absolute configurations of millefoliumons A–F were confirmed by experimental and calculated electronic circular dichroism data (ECD), and 13C‐NMR calculations and DP4+ probability analysis. All compounds displayed the approximate tendency to inhibit the nitric oxide (NO) release in lipopolysaccharide (LPS)‐induced BV2 cells.