Synthesis, Characterization and Antimicrobial Activities of Silver Nanoparticles coated [1,3] Thiazin-4-One derivatives

Heterocyclic compounds have been used extensively used in pharmaceutical research area due to their effective biological activities. Thiazine, a heterocyclic compound with four carbon atoms, one nitrogen and one sulfur atoms which have promising pharmacological activities that have attracted the att...

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Bibliographic Details
Published inJournal of physics. Conference series Vol. 1294; no. 5; pp. 52028 - 52038
Main Authors Mohammed, Leqaa A, Nief, Olfat A, Askar, Firyal W, Majeed, Abdulwahhab H
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.09.2019
Subjects
Antiinfectives and antibacterials
Atomic force microscopes
Atomic force microscopy
Base metal
biological activities
Biological effects
Chemical reduction
Dilution
E coli
Heterocyclic compounds
Imines
Klebsiella
Nanoparticles
NMR
Nuclear magnetic resonance
Physics
Schiff bases
Silver
Silver nanoparticles
Spectrophotometry
Synthesis
Thiazine
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Summary:Heterocyclic compounds have been used extensively used in pharmaceutical research area due to their effective biological activities. Thiazine, a heterocyclic compound with four carbon atoms, one nitrogen and one sulfur atoms which have promising pharmacological activities that have attracted the attention of scientists and researchers. In this research [3-(4-Amino-phenyl)-2-(4-nitro-phenyl)-2,3-dihydro-benzo[e][1,3]thiazin-4-one [comp. (2)] was used as a synthone for the preparation of Schiff bases [comp.(3)-(7)]. The synthesis compounds were characterized by FT-IR, 1H NMR and spectrophotometric methods. Furthermore, silver nanoparticles was prepared by chemical reduction and characterized by X-Ray diffraction (XRD), infra-red spectrum (FTIR), atomic force microscope (AFM) and scanning electron microscope (SEM). The Ag NPs was used as a base nano metal for preparing Schiff bases-Ag NPs derivatives. The pure Ag NPs and Ag NPs functionalized Schiff bases nano compounds were used to check their effectiveness against four different types of bacterial (Staphylococcus aurous, Staphylococcus epidermidis, Escherichia coli and Klebsiella sp.) and one type of fungal (Candida albicans) by a serial dilution method.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1294/5/052028