Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

An efficient 1,4‐dihydropyridine synthesis under mild conditions has been developed. Numerous substrates were tested, with yields of 1,4‐dihydropridines ranging from good to excellent and a wide range of functional group tolerance. A549, HT‐29, and HepG2 cancer cells were used to investigate the ant...

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Published inChemistry & biodiversity Vol. 20; no. 8; pp. e202201158 - n/a
Main Authors Merugu, Santha Kumari, Krishnan K, V. B. R., Kumar K, Ravi, Ansari, Siddique Akber, Ansari, Irfan Aamer, Bollikolla, Hari Babu
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.08.2023
Subjects
Adenosine
aldehydes
anticancer activity
Anticancer properties
Dihydropyridine
Functional groups
imidazole hydrochloride
molecular docking studies
Substrates
Synthesis
unsymmetrical 1,4-dihydropyridines
unsymmetrical 1,4-dihydropyridines
molecular docking studies
aldehydes
anticancer activity
imidazole hydrochloride
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Summary:An efficient 1,4‐dihydropyridine synthesis under mild conditions has been developed. Numerous substrates were tested, with yields of 1,4‐dihydropridines ranging from good to excellent and a wide range of functional group tolerance. A549, HT‐29, and HepG2 cancer cells were used to investigate the anticancer efficacy of each of the produced compounds. Additionally, in‐silico docking studies were conducted to understand the structure‐based features of the anticancer mechanism with the cancer medication target of Adenosine A2A receptor as well as the molecular level interactions of the compounds.
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ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202201158