Creation of porous synthetic matrices of polylactic acid (PLA) with ibuprofen impregnation using supercritical fluid

• Published in: Journal of physics. Conference series Vol. 2573; no. 1; pp. 12008 - 12014
• Main Authors: Rastegaev, E K, Gilmutdinov, I I, Sandugey, N S, Kuznetcova, I V, Sabirzyanov, A N
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.09.2023
• Subjects: Chemical synthesis; Functional materials; Hydroxyapatite; Ibuprofen; Parameter identification; Physical properties; Physics; Polylactic acid; Polymer matrix composites; Polymers; Pore formation; Spectral methods; Supercritical fluids; Surgical implants; Tissue engineering
• ISSN: 1742-6588; 1742-6596
• DOI: 10.1088/1742-6596/2573/1/012008

The synthesis of highly porous biosoluble polymer matrices using supercritical and subcritical fluid technologies is a promising direction in the development of functional materials for modern tissue engineering and regenerative medicine. The subject of the article is the pore formation, the creation of composite polymer matrices and the impregnation of medicinal substances into the resulting structures using supercritical fluids, as well as the identification of patterns of influence of thermodynamic parameters on the physical properties of the resulting structures. Experimental studies were carried out on the creation of PLA polymer implants, composites of PLA-hydroxyapatite HAP with impregnation into the resulting ibuprofen matrix. The obtained samples were studied using spectral methods of analysis and differential scanning calorimetry.