From Nares to Wound: Exploring the mechanisms for Staphylococcal surgical site infections, implications for infection prevention

Abstract Surgical site infections (SSIs) are important healthcare-associated infections, leading to increased morbidity and mortality, healthcare costs, and prolonged hospital stays. Staphylococcus aureus is an important and common microbial cause of SSI. Nasal carriage of S. aureus has been shown t...

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Published inAntimicrobial stewardship & healthcare epidemiology : ASHE Vol. 3; no. 1; p. e130
Main Authors Troeman, Darren P. R., Kluytmans, Jan A. J. W.
Format Journal Article
LanguageEnglish
Published Cambridge Cambridge University Press 01.01.2023
Subjects
Air flow
Etiology
Nose
Skin
Staphylococcus infections
Surgical site infections
Ventilation
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Summary:Abstract Surgical site infections (SSIs) are important healthcare-associated infections, leading to increased morbidity and mortality, healthcare costs, and prolonged hospital stays. Staphylococcus aureus is an important and common microbial cause of SSI. Nasal carriage of S. aureus has been shown to be an important determinant for the development of SSI, and interventions aimed at eradicating preoperative nasal carriage are associated with a reduced risk of infection. Yet, it is not entirely clear how the nasally residing S. aureus causes SSI at distant body sites. In this commentary, we describe our view on how S. aureus can be transported from the nares to the incision site during surgery. In addition, we shed light on the implications of our view for infection prevention research.
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ISSN:2732-494X
2732-494X
DOI:10.1017/ash.2023.197