Three Undescribed Flavonoids and Amide from Abrus mollis Hance with Hepatoprotective Effects

Through a phytochemical investigation of Abrus mollis Hance, a folk medicinal plant in China, we isolated and identified three undescribed compounds, including two flavonoids and one amides alkaloid, along with nine known from this plant. Their structures were elucidated by analyses of 1D, 2D NMR, H...

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Published inChemistry & biodiversity Vol. 20; no. 7; pp. e202300696 - n/a
Main Authors Du, Kaicheng, Li, Xingyao, Zheng, Changwei, Ju, Yan, Meng, Dali
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.07.2023
Subjects
Abrus - chemistry
Abrus mollis
Alkaloids - pharmacology
amide
Amides
Amides - pharmacology
Cell survival
DP4
Flavonoids
Flavonoids - chemistry
hepatoprotective
Herbal medicine
Medicinal plants
NMR
Nuclear magnetic resonance
Plant Extracts - chemistry
Survival
Two dimensional analysis
DP4
amide
flavonoids
Abrus mollis
hepatoprotective
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Summary:Through a phytochemical investigation of Abrus mollis Hance, a folk medicinal plant in China, we isolated and identified three undescribed compounds, including two flavonoids and one amides alkaloid, along with nine known from this plant. Their structures were elucidated by analyses of 1D, 2D NMR, HR‐ESI‐MS, ECD, and DP4+ analysis. Furthermore, we evaluated the hepatoprotective effects of all twelve compounds on D‐GalN‐induced Brl‐3 A cells. According to the results, at a concentration of 25 μM, the cell survival rates were observed to be 71.92±0.34 %, 70.03±1.29 %, and 69.11±1.90 % for compound 2, 4, and 11, respectively. Further experimental studies showed that compound 2 (EC50 5.76±0.37 μM) showed more significant protective activity than the bicyclol.
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content type line 23
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300696