A novel report of cig‐FISH and cytogenetics in POEMS syndrome

• Published in: American journal of hematology Vol. 83; no. 11; pp. 840 - 841
• Main Authors: Bryce, Alan H., Ketterling, Rhett P., Gertz, Morie A., Lacy, Martha, Knudson, Ryan A., Kumar, Shaji, Kyle, Robert A., Fonseca, Rafael, Greipp, Phillip R., Lust, John A., Rajkumar, Vincent S., Hayman, Suzanne R., Buadi, Francis, Russell, Stephen J., Zeldenrust, Stephen R., Dispenzieri, Angela
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2008
• Subjects: Adult; Aged; Chromosome Aberrations; Chromosomes, Human, Pair 11 - genetics; Chromosomes, Human, Pair 13 - genetics; Cohort Studies; Female; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; POEMS Syndrome - genetics
• ISSN: 0361-8609; 1096-8652
• DOI: 10.1002/ajh.21285

POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg‐FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg‐FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg‐FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.