Factor V Leiden and prothrombin 21210G>A mutation and paediatric ischaemic stroke: a case-control study and two meta-analyses

• Published in: Acta Paediatrica Vol. 99; no. 8; pp. 1168 - 1174
• Main Authors: Laugesaar, R, Kahre, T, Kolk, A, Uustalu, Ü, Kool, P, Talvik, T
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2010; Blackwell
• Subjects: Biological and medical sciences; Case-control study; Epidemiology; Factor V Leiden; General aspects; Medical sciences; Meta-analysis; Neurology; Paediatric stroke; Prothrombin 20210G>A mutation; Public health. Hygiene; Public health. Hygiene-occupational medicine; Vascular diseases and vascular malformations of the nervous system; Pediatrics; Prothrombin 20210G>A mutation; Factor V Leiden; Cardiovascular disease; Case-control study; Review; Case control study; Paediatric stroke; Epidemiology; Evidence-based medicine; Metaanalysis; Vascular disease; Genetics; Child; Cerebrovascular disease; Public health; Human; Nervous system diseases; Stroke; Evidence-based practice; Cerebral disorder; Meta-analysis; Thrombophilia; Central nervous system disease; Brain ischemia; Prothrombin; Mutation; Coagulation factor
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.2010.01784.x

Aim:  To determine whether factor V Leiden (FVL) and prothrombin (PT) 20210G>A mutation are associated with paediatric ischaemic stroke. Methods:  The study consisted of two parts. Case–control study included neuroradiologically confirmed paediatric ischaemic stroke patients from two tertiary children’s hospitals in Estonia. For control group, DNA was obtained from 400 anonymous screening test cards of newborns born consecutively in all delivery departments of Estonia in January 2005. Meta‐analyses was performed to assess the association between paediatric sinovenous thrombosis and FVL and PT 20210G>A. Results:  A total of 75 children (45 boys, 30 girls) were included into the case–control study: 19 with childhood arterial ischaemic stroke, 49 with perinatal arterial ischaemic stroke and seven with cerebral venous thrombosis. Both FVL and PT 20210G>A occurred significantly more frequently among patients with sinovenous thrombosis compared with controls (OR = 12.9; 95% CI: 2.3–73.0 and OR = 11.9; 95% CI: 2.1–67.2, respectively). The difference was not significant between childhood/perinatal arterial ischaemic stroke and controls. Meta‐analyses (including our study) revealed that both FVL and PT 20210G>A are associated with paediatric sinovenous thrombosis (OR = 3.1; 95% CI: 1.8–5.5 and OR = 3.1; 95% CI: 1.4–6.8, respectively). Conclusion:  FVL and PT 20210G>A are associated with paediatric sinovenous thrombosis.