Bibenzyl–Phenylpropane Hybrids with Immunosuppressive Activities from Dendrobium Nobile Lindl

• Published in: Chemistry & biodiversity Vol. 21; no. 5; pp. e202400283 - n/a
• Main Authors: Wang, Qing‐Tao, Wang, Chao‐Fan, Liu, Ying, Zhan, Rui
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.05.2024
• Subjects: Animals; B-Lymphocytes - drug effects; Bibenzyls - chemistry; Bibenzyls - isolation & purification; Bibenzyls - pharmacology; bibenzyl–phenylpropane hybrid; Bio-assays; Bioassays; Cell Proliferation - drug effects; Concanavalin A - antagonists & inhibitors; Concanavalin A - pharmacology; Dendrobium - chemistry; Dendrobium nobile Lindl; Dose-Response Relationship, Drug; Hybrids; immunosuppressive activity; Immunosuppressive Agents - chemistry; Immunosuppressive Agents - isolation & purification; Immunosuppressive Agents - pharmacology; Lipopolysaccharides - antagonists & inhibitors; Lipopolysaccharides - pharmacology; Lymphocytes; Lymphocytes B; Lymphocytes T; Mice; Molecular Structure; Structure-Activity Relationship; T-Lymphocytes - drug effects; immunosuppressive activity; bibenzyl–phenylpropane hybrid; Dendrobium nobile Lindl
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202400283

Fifteen bibenyls and four fluorenones, including five new bibenzyl–phenylpropane hybrids, were isolated from the aerial part of Dendrobium nobile Lindl. Their structures were determined by spectroscopic methods. Bioassay on the LPS–induced proliferations of mouse splenic B lymphocytes, and Con A‐induced T lymphocytes showed that compounds 1, 2, and 14 showed excellent immunosuppressive activities with IC50 values of 1.23, 1.01, and 3.87 μM, respectively, while compounds 3–4, 7, 10, 13, and 15 exhibited moderate immunosuppressive activities with IC50 values ranging from 6.89 to 14.2 μM.