Analysis of H-2 determinants recognized during the induction of H-Y-immune cytotoxic T cells by monoclonal antibodies in vitro

Monoclonal antibodies directed to the D region of H-2(k) when present during in vitro culture inhibit the generation of CBA/H and C3H.H-2(o) H-Y-immune cytotoxic T cells . Monoclonal antibodies directed to the I-A(k) and I-E(k) region specifically inhibited induction of CBA/H H-Y-immune cytotoxic T...

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Published inThe Journal of experimental medicine Vol. 154; no. 2; pp. 563 - 568
Main Authors Brenan, M, Müllbacher, A
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 01.08.1981
Subjects
Animals
Antibodies - pharmacology
Antibodies, Monoclonal
Cytotoxicity, Immunologic
Dose-Response Relationship, Immunologic
Epitopes
H-2 Antigens - immunology
H-Y Antigen - immunology
Killer Cells, Natural - immunology
Male
Mice
Mice, Inbred C3H - immunology
Mice, Inbred CBA - immunology
T-Lymphocytes - immunology
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Summary:Monoclonal antibodies directed to the D region of H-2(k) when present during in vitro culture inhibit the generation of CBA/H and C3H.H-2(o) H-Y-immune cytotoxic T cells . Monoclonal antibodies directed to the I-A(k) and I-E(k) region specifically inhibited induction of CBA/H H-Y-immune cytotoxic T cells only when they were present simultaneously in culture. These findings show T helper cell requirement for CBA/H H-Y-immune cytotoxic T cell induction, and suggest that two I region-coded restriction antigens for T helper cells are involved.
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ISSN:0022-1007
1540-9538
DOI:10.1084/jem.154.2.563