Monitoring of optical properties of tumors during laser plasmon photothermal therapy

• Published in: Journal of biophotonics Vol. 17; no. 4; pp. e202300322 - n/a
• Main Authors: Genin, Vadim D., Bucharskaya, Alla B., Kirillin, Mikhail Yu, Kurakina, Daria A., Navolokin, Nikita A., Terentyuk, Georgy S., Khlebtsov, Boris N., Khlebtsov, Nikolai G., Maslyakova, Galina N., Tuchin, Valery V., Genina, Elina A.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.04.2024; Wiley Subscription Services, Inc
• Subjects: Absorption; Absorption bands; Absorption spectra; gold nanorods; Haemoglobin; Hemoglobin; Infrared lasers; Irradiation; Kidney cancer; Laser radiation; Lasers; Nanorods; Neoplasms; Optical properties; plasmonic photothermal therapy; Plasmons; Semiconductor lasers; Tumors; Water depth; kidney cancer; optical properties; gold nanorods; plasmonic photothermal therapy
• ISSN: 1864-063X; 1864-0648; 1864-0648
• DOI: 10.1002/jbio.202300322

We studied grafted tumors obtained by subcutaneous implantation of kidney cancer cells into male white rats. Gold nanorods with a plasmon resonance of about 800 nm were injected intratumorally for photothermal heating. Experimental irradiation of tumors was carried out percutaneously using a near‐infrared diode laser. Changes in the optical properties of the studied tissues in the spectral range 350–2200 nm under plasmonic photothermal therapy (PPT) were studied. Analysis of the observed changes in the absorption bands of water and hemoglobin made it possible to estimate the depth of thermal damage to the tumor. A significant decrease in absorption peaks was observed in the spectrum of the upper peripheral part and especially the tumor capsule. The obtained changes in the optical properties of tissues under laser irradiation can be used to optimize laboratory and clinical PPT procedures. Grafted subcutaneous tumors obtained by subcutaneous transplantation cultured kidney cancer cell into male albino rats were investigated. Gold nanorods with the plasmon resonance were injected intratumorally. Changes in the optical properties of the studied tissues as a result of plasmonic photothermal therapy have been experimentally studied.