Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent...

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Published inChemistry & biodiversity Vol. 21; no. 6; pp. e202400402 - n/a
Main Authors El Menyiy, Naoual, Elouafy, Youssef, Moubachir, Rania, Abdnim, Rhizlan, Benali, Taoufiq, Taha, Douae, Khalid, Asaad, Abdalla, Ashraf N., Hamza, Siddiqa M. A., Elhadi Ibrahim, Salma, El‐Shazly, Mohamed, Zengin, Gokhan, Bouyahya, Abdelhakim
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.06.2024
Subjects
Alzheimer's disease
Angiogenesis
Animal diseases
Animal models
anti-inflammatory
anticancer
Apoptosis
Aquatic plants
Bioactive compounds
Biological properties
Cognitive ability
Cytotoxicity
Gastrodin
Immunomodulation
Inflammation
Ischemia
Molecular modelling
Movement disorders
Neurodegenerative diseases
Neuroprotection
neuroprotective
Parkinson's disease
Pharmacology
Rhizomes
Tumors
anti-inflammatory
apoptosis
neuroprotective
anticancer
Gastrodin
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Abstract Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.
AbstractList Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti-inflammatory, antioxidant, anti-apoptotic, and anti-tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.
Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti-inflammatory, antioxidant, anti-apoptotic, and anti-tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti-inflammatory, antioxidant, anti-apoptotic, and anti-tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.
Abstract Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata , exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.
Author Benali, Taoufiq
Bouyahya, Abdelhakim
El Menyiy, Naoual
Taha, Douae
Elhadi Ibrahim, Salma
Elouafy, Youssef
Zengin, Gokhan
Khalid, Asaad
El‐Shazly, Mohamed
Moubachir, Rania
Hamza, Siddiqa M. A.
Abdalla, Ashraf N.
Abdnim, Rhizlan
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  organization: Mohammed V University in Rabat
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Gastrodin
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e_1_2_9_35_1
Zhu M. (e_1_2_9_94_1) 2018; 2018
Li C. (e_1_2_9_109_1) 2012; 7
e_1_2_9_77_1
e_1_2_9_96_1
e_1_2_9_12_1
e_1_2_9_54_1
e_1_2_9_101_1
e_1_2_9_105_1
e_1_2_9_124_1
e_1_2_9_39_1
e_1_2_9_120_1
e_1_2_9_16_1
e_1_2_9_58_1
e_1_2_9_20_1
e_1_2_9_62_1
e_1_2_9_89_1
e_1_2_9_24_1
e_1_2_9_43_1
e_1_2_9_66_1
e_1_2_9_85_1
e_1_2_9_8_1
e_1_2_9_81_1
e_1_2_9_4_1
e_1_2_9_113_1
e_1_2_9_117_1
e_1_2_9_28_1
e_1_2_9_47_1
e_1_2_9_74_1
e_1_2_9_51_1
e_1_2_9_78_1
e_1_2_9_13_1
e_1_2_9_32_1
e_1_2_9_55_1
e_1_2_9_97_1
e_1_2_9_70_1
e_1_2_9_127_1
e_1_2_9_100_1
e_1_2_9_123_1
e_1_2_9_104_1
e_1_2_9_17_1
e_1_2_9_36_1
e_1_2_9_59_1
e_1_2_9_63_1
e_1_2_9_40_1
e_1_2_9_21_1
e_1_2_9_67_1
e_1_2_9_44_1
e_1_2_9_86_1
e_1_2_9_7_1
e_1_2_9_82_1
e_1_2_9_3_1
e_1_2_9_112_1
e_1_2_9_116_1
e_1_2_9_25_1
e_1_2_9_48_1
e_1_2_9_29_1
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Snippet Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented...
Abstract Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata , exhibits a diverse range of biological activities. With...
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SubjectTerms Alzheimer's disease
Angiogenesis
Animal diseases
Animal models
anti-inflammatory
anticancer
Apoptosis
Aquatic plants
Bioactive compounds
Biological properties
Cognitive ability
Cytotoxicity
Gastrodin
Immunomodulation
Inflammation
Ischemia
Molecular modelling
Movement disorders
Neurodegenerative diseases
Neuroprotection
neuroprotective
Parkinson's disease
Pharmacology
Rhizomes
Tumors
Title Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbdv.202400402
https://www.ncbi.nlm.nih.gov/pubmed/38573028
https://www.proquest.com/docview/3069192863/abstract/
https://www.proquest.com/docview/3033006474/abstract/
Volume 21
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