Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent...

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Published inChemistry & biodiversity Vol. 21; no. 6; pp. e202400402 - n/a
Main Authors El Menyiy, Naoual, Elouafy, Youssef, Moubachir, Rania, Abdnim, Rhizlan, Benali, Taoufiq, Taha, Douae, Khalid, Asaad, Abdalla, Ashraf N., Hamza, Siddiqa M. A., Elhadi Ibrahim, Salma, El‐Shazly, Mohamed, Zengin, Gokhan, Bouyahya, Abdelhakim
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.06.2024
Subjects
Alzheimer's disease
Angiogenesis
Animal diseases
Animal models
anti-inflammatory
anticancer
Apoptosis
Aquatic plants
Bioactive compounds
Biological properties
Cognitive ability
Cytotoxicity
Gastrodin
Immunomodulation
Inflammation
Ischemia
Molecular modelling
Movement disorders
Neurodegenerative diseases
Neuroprotection
neuroprotective
Parkinson's disease
Pharmacology
Rhizomes
Tumors
anti-inflammatory
apoptosis
neuroprotective
anticancer
Gastrodin
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Summary:Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.
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ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202400402