Portal and Hepatic Vein Embolization versus Portal Venous Embolization Alone in Cirrhotic and Noncirrhotic Swine: A Pilot Study

• Published in: Journal of vascular and interventional radiology Vol. 36; no. 6; pp. 1042 - 1050.e2
• Main Authors: Tefera, Jonathan, Kuhn, Tom N., Matuschewski, Nickolai J., Meister, Ellen, Nguyenová, Jana, Kao, Tabea, Mutonga, Martin, Bitar, Ryan, Kahl, Vinzent H., Zhang, Xuchen, Shewarega, Annabella, Chapiro, Julius, Madoff, David C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2025
• Subjects: Animals; Disease Models, Animal; Embolization, Therapeutic - methods; Female; Hepatic Veins - diagnostic imaging; Hepatic Veins - physiopathology; Liver - blood supply; Liver - diagnostic imaging; Liver - pathology; Liver Cirrhosis - diagnostic imaging; Liver Cirrhosis - therapy; Liver Cirrhosis, Experimental - diagnostic imaging; Liver Cirrhosis, Experimental - pathology; Liver Cirrhosis, Experimental - therapy; Liver Regeneration; Pilot Projects; Portal Vein - diagnostic imaging; Portal Vein - physiopathology; Sus scrofa; Swine; Time Factors; Tomography, X-Ray Computed; CT; nBCA; H&E; HVE; PVL; HCC; LVD; FLR; PVE; ALPPS
• ISSN: 1051-0443; 1535-7732
• DOI: 10.1016/j.jvir.2025.02.028

To evaluate the effectiveness of combined portal vein embolization (PVE) and hepatic vein embolization (HVE) compared with that of PVE alone in cirrhotic and noncirrhotic swine. Sixteen Yorkshire pigs were included in this study. In the cirrhotic group (n = 8) and noncirrhotic group (n = 8), subjects underwent embolization according to established protocols. Computed tomography (CT) scans were acquired before and at 2- and 4-week intervals following the embolization. Liver volumes were segmented in the portal venous phase. Student t test with a significance level at P < .05 was used. Across all swine, the future liver remnant (FLR) was significantly larger after PVE + HVE than after PVE at 2 weeks (24.12% [95% CI, 15.36%–32.88%] vs 12.75% [95% CI, 7.43%–18.07%]; P = .021) and 4 weeks (23.23% [95% CI, 15.79%–33.47%] vs 15.08% [95% CI, 9.98%–20.87%]; P = .043) after embolization. In the cirrhotic group, the FLR increase was greater following PVE + HVE than after PVE at 2 weeks (20.85% [95% CI, 14.40%–27.30%] vs 8.66% [95% CI, 6.47%–10.86%]; P = .0089) and 4 weeks (19.27% [95% CI, 17.87%–20.67%] vs 13.33% [95% CI, 9.23%–13.33%]; P = .0003) after embolization. PVE + HVE resulted in greater FLR hypertrophy than PVE alone, indicating that cirrhotic livers may benefit from the addition of HVE. [Display omitted]