The aromatase expression in myomas and myometriums of women in reproduction and perimenopausal age

Uterine myomas represent one of the most common female pathologies. Uterine smooth muscle myomas or fibromas are benign tumours which respond to hormones and their etiology induces wide interest. The myomas were found to contain aromatase and, in addition, cells of the myomas were found to synthesiz...

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Published inFolia histochemica et cytobiologica Vol. 47; no. 3; pp. 497 - 504
Main Authors Madej, Paweł, Plewka, Andrzej, Plewka, Danuta, Paleń, Piotr, Nowaczyk, Grazyna, Bogunia, Edyta, Marczyński, Jacek, Waloszek, Józef
Format Journal Article
LanguageEnglish
Published Poland Wydawnictwo Via Medica 01.01.2009
Subjects
Adult
Aromatase - biosynthesis
Aromatase - metabolism
Blotting, Western
Female
Humans
Immunohistochemistry
Maternal Age
Middle Aged
Myoma - enzymology
Myoma - metabolism
Myoma - pathology
Myometrium - enzymology
Myometrium - metabolism
Perimenopause
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Summary:Uterine myomas represent one of the most common female pathologies. Uterine smooth muscle myomas or fibromas are benign tumours which respond to hormones and their etiology induces wide interest. The myomas were found to contain aromatase and, in addition, cells of the myomas were found to synthesize estrogen. This study was conducted on patients with the myomas, in either generative age or in the perimenopausal period. Expression of aromatase was detected in patients of various age, with large or small uterine myomas, using an immunohistochemical technique. In addition expression of the enzyme was examined at the periphery of every myoma.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0239-8508
1897-5631
DOI:10.2478/v10042-009-0105-0