Rose Petal Extract ( Rosa gallica ) Exerts Skin Whitening and Anti-Skin Wrinkle Effects

• Published in: Journal of medicinal food Vol. 23; no. 8; p. 870
• Main Authors: Song, Young-Ran, Lim, Won-Chul, Han, Ahram, Lee, Myung-Hee, Shin, Eun Ju, Lee, Kwang-Min, Nam, Tae-Gyu, Lim, Tae-Gyu
• Format: Journal Article
• Language: English
• Published: United States 01.08.2020
• Subjects: Cells, Cultured; Fibroblasts; Humans; JNK Mitogen-Activated Protein Kinases - metabolism; MAP Kinase Signaling System - drug effects; Matrix Metalloproteinase 1 - metabolism; Melanins - metabolism; Melanoma, Experimental; Plant Extracts - pharmacology; Rosa - chemistry; Skin - drug effects; Skin Aging - drug effects; Skin Lightening Preparations - pharmacology; Ultraviolet Rays; melanin; MMP-1 • Rosa gallica • skin whitening; wrinkle formation
• DOI: 10.1089/jmf.2020.4705

We sought to investigate the effect of extracts from petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinical trial with an RPE-containing formulation enhanced skin brightness (L* value) significantly. The underlying mechanism responsible was determined to be associated with mitogen-activated protein kinase (MAPK) activation. In addition, RPE exhibited anti-wrinkle formation activity of human dermal fibroblasts by suppressing matrix metalloproteinase (MMP)-1 level. study, RPE also inhibited solar ultraviolet-stimulated MMP-1 level by c-Jun regulation. Overall, our findings indicate that RPE evokes skin whitening and anti-wrinkle formation activity by regulating intracellular signaling, supporting its utility as an ingredient for skin whitening and anti-wrinkle cosmetic products.