Rose Petal Extract ( Rosa gallica ) Exerts Skin Whitening and Anti-Skin Wrinkle Effects
We sought to investigate the effect of extracts from petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinica...
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Published in | Journal of medicinal food Vol. 23; no. 8; p. 870 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.08.2020
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Subjects | |
Online Access | Get more information |
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Summary: | We sought to investigate the effect of extracts from
petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinical trial with an RPE-containing formulation enhanced skin brightness (L* value) significantly. The underlying mechanism responsible was determined to be associated with mitogen-activated protein kinase (MAPK) activation. In addition, RPE exhibited anti-wrinkle formation activity of human dermal fibroblasts by suppressing matrix metalloproteinase (MMP)-1 level.
study, RPE also inhibited solar ultraviolet-stimulated MMP-1 level by c-Jun regulation. Overall, our findings indicate that RPE evokes skin whitening and anti-wrinkle formation activity by regulating intracellular signaling, supporting its utility as an ingredient for skin whitening and anti-wrinkle cosmetic products. |
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ISSN: | 1557-7600 |
DOI: | 10.1089/jmf.2020.4705 |