Serum proteolytic activity during the growth of C6 astrocytoma

Tumor growth is dependent on the ability of neoplastic cells to induce angiogenesis. Blood-vessel remodeling requires the reconstruction of the nonfibrous proteins and type IV collagen components of the basement membrane. This study has assessed the influence of the growth of C6 astrocytoma cells in...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 77; no. 4; p. 595
Main Authors Vaithilingam, I S, McDonald, W, Brown, N K, Stroude, E, Cook, R A, Del Maestro, R F
Format Journal Article
LanguageEnglish
Published United States 01.10.1992
Subjects
Animals
Astrocytoma - enzymology
Astrocytoma - pathology
Brain Neoplasms - enzymology
Brain Neoplasms - pathology
Cell Division - physiology
Matrix Metalloproteinase 9
Membrane Proteins - metabolism
Microbial Collagenase - blood
Neoplasm Transplantation
Peptide Hydrolases - blood
Rats
Rats, Inbred Strains
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Summary:Tumor growth is dependent on the ability of neoplastic cells to induce angiogenesis. Blood-vessel remodeling requires the reconstruction of the nonfibrous proteins and type IV collagen components of the basement membrane. This study has assessed the influence of the growth of C6 astrocytoma cells in the rat spheroid implantation model on serum general protease and type IV collagenase activity. The results demonstrate that general protease activity increased in serum, reaching maximum values on Day 6 and Day 13 following spheroid implantation, and that type IV collagenase activity increased in serum, obtaining maximum values on Day 8 and Day 15. The measurement of serum proteolytic activity may be of value in the detection of recurrent tumors.
ISSN:0022-3085
DOI:10.3171/jns.1992.77.4.0595