Alcohol exposure before pregnancy: effect on GABA levels and turnover in rat offspring

The GABA levels and turnover rates in various brain areas from 2-month-old rats born to mothers who consumed 20% (v/v) alcohol during 1 month only before pregnancy, were investigated. A decreased level was found in the olfactory tubercules and an increase was observed in the hypothalamus. The turnov...

Full description

Saved in:
Bibliographic Details
Published inAlcohol and alcoholism (Oxford) Vol. 28; no. 2; p. 175
Main Authors Ledig, M, Simler, S, Ciesielski, L, Mandel, P
Format Journal Article
LanguageEnglish
Published England 01.03.1993
Subjects
Animals
Animals, Newborn
Brain - physiopathology
Brain Mapping
Ethanol - toxicity
Female
Fetal Alcohol Spectrum Disorders - physiopathology
Frontal Lobe - physiopathology
Hippocampus - physiopathology
Hypothalamus - physiopathology
Male
Mothers
Olfactory Bulb - physiopathology
Olfactory Pathways - physiopathology
Pregnancy
Rats
Rats, Wistar
Online AccessGet more information

Cover

More Information
Summary:The GABA levels and turnover rates in various brain areas from 2-month-old rats born to mothers who consumed 20% (v/v) alcohol during 1 month only before pregnancy, were investigated. A decreased level was found in the olfactory tubercules and an increase was observed in the hypothalamus. The turnover rates were reduced in both areas, whereas an increase was observed in the frontal cortex. These results indicate that biochemical alterations may occur in the offspring even if the fetus did not develop under alcoholization.
ISSN:0735-0414
DOI:10.1093/oxfordjournals.alcalc.a045358