Neutrophils and Bacterial Coinfection: Aiding and Abetting

Bacterial pneumonia remains a leading cause of hospitalization and is the leading cause of death in children worldwide. Neutrophil accumulation is a hallmark of pneumonia, and unregulated and excessive neutrophil inflammation is associated with more severe disease. It is increasingly recognized that...

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Bibliographic Details
Published inAmerican journal of respiratory cell and molecular biology Vol. 59; no. 6; pp. 668 - 669
Main Authors Bratcher, Preston E, Malcolm, Kenneth C
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.12.2018
Subjects
Antibiotics
Bacteria
Bacterial infections
Children
Cystic fibrosis
Drug resistance
Experiments
Infections
Inflammation
Leukocytes (neutrophilic)
Lung diseases
Mortality
Neutrophils
Pathogenesis
Pathogens
Pneumonia
United States > US
Colorado
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Summary:Bacterial pneumonia remains a leading cause of hospitalization and is the leading cause of death in children worldwide. Neutrophil accumulation is a hallmark of pneumonia, and unregulated and excessive neutrophil inflammation is associated with more severe disease. It is increasingly recognized that polymicrobial bacterial infections occur during pneumonia, and the treatment and outcome of these infections present clinical challenges. Infections with two pathogens can synergistically drive more severe disease than either pathogen alone, resulting in increased lung injury, disseminated disease, and death. The observations in this work and other studies (8) may provide a framework for studying the mechanisms of polymicrobial interactions. An important finding is that targeting of a single pathogen during a coinfection affects the survival of both pathogens.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:1044-1549
1535-4989
DOI:10.1165/rcmb.2018-0250ED