Design and application of ion concentration polarization for preconcentrating charged analytes

Micro/nanofluidic devices integrated with ion concentration polarization (ICP) phenomenon have been used to preconcentrate low-abundant molecules for separation and detection purposes. This work reviews ICP-based devices focused on electrokinetic fundamentals of ICP in microfluidics and related desi...

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Bibliographic Details
Published inPhysics of Fluids Vol. 33; no. 5
Main Authors Gholinejad, Majid, Jabari Moghadam, Ali, Phan, Dinh-Tuan, Miri, Amir K., Mousavi Shaegh, Seyed Ali
Format Book Review Journal Article
LanguageEnglish
Published Melville American Institute of Physics 01.05.2021
Subjects
Desalination
Design factors
Devices
Electrodialysis
Electrokinetics
Fluid dynamics
Fluidics
Ion concentration
Microfluidics
Nanofluids
Physics
Polarization
Separation
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Summary:Micro/nanofluidic devices integrated with ion concentration polarization (ICP) phenomenon have been used to preconcentrate low-abundant molecules for separation and detection purposes. This work reviews ICP-based devices focused on electrokinetic fundamentals of ICP in microfluidics and related design factors. We discuss various designs of ICP devices and then provide insight on the role of design factors in ICP function. In addition, fabrication methods and relevant materials for making ICP devices and nanojunctions are explained. This work provides the most up-to-date applications of ICP with emphasis on active and passive methods in controlling and stabilizing streams of preconcentrated molecules to enhance the separation and detection efficiency in diagnostics, desalination, and electrodialysis.
ISSN:1070-6631
1089-7666
DOI:10.1063/5.0038914